Ipamorelin: Dosage, Protocol, and Research Guide
Selective growth hormone secretagogue (GHS) that mimics ghrelin action without affecting cortisol or prolactin levels
Mechanism
Binds selectively to ghrelin receptors (GHSR) in the pituitary and hypothalamus, stimulating pulsatile GH release without significantly affecting ACTH, cortisol, or prolactin. Maintains negative feedback mechanisms, preventing excessive GH elevation.
Protocol at a glance
| Starting dose | 100mcg |
|---|---|
| Maintenance dose | 100-300mcg |
| Maximum dose | 300mcg |
| Frequency | 1-3 times daily |
| Typical duration | Continuous use possible, cycling optional |
| Route | Subcutaneous |
| Injection site | Abdomen or thigh |
| Timing | In fasted state to maximize GH release |
Side effects
- Mild headaches (transient)
- Temporary injection site reactions
- Minimal hormonal side effects
Contraindications
- Active cancer
- Pregnancy
- Severe organ dysfunction
Protocol notes
- Does not increase cortisol or prolactin unlike other GHS peptides
- Helps restore natural pulsatile GH release
- Often stacked with GHRH peptides like Mod-GRF or Tesamorelin
- Enhances sleep quality through natural GH cycles
- Promotes tissue repair and collagen synthesis
Frequently asked questions
What is Ipamorelin used for?
Ipamorelin has been studied for: Selective growth hormone secretagogue (GHS) that mimics ghrelin action without affecting cortisol or prolactin levels Mechanism: Binds selectively to ghrelin receptors (GHSR) in the pituitary and hypothalamus, stimulating pulsatile GH release without significantly affecting ACTH, cortisol, or prolactin. For research purposes only — consult a licensed physician before use.
What is the standard Ipamorelin dose?
Starting dose in published protocols is typically 100mcg, titrating up to a maintenance dose of 100-300mcg (max 300mcg). Frequency: 1-3 times daily. Route: Subcutaneous. Always confirm with a medical professional.
How is Ipamorelin administered?
Ipamorelin is typically administered subcutaneous at the abdomen or thigh. Timing: In fasted state to maximize GH release. Rotate injection sites to avoid tissue irritation.
What are the side effects of Ipamorelin?
Reported side effects include: Mild headaches (transient), Temporary injection site reactions, Minimal hormonal side effects. Individual responses vary. Contact a healthcare provider if you experience unexpected symptoms.
Who should not take Ipamorelin?
Contraindications in published research include: Active cancer, Pregnancy, Severe organ dysfunction. This is not an exhaustive list — consult a physician before starting any peptide protocol.
How long does Ipamorelin take to work?
Timelines vary by individual and goal. Published protocols run for Continuous use possible, cycling optional. Track doses, side effects, and biomarker changes over time to measure your own response rather than relying on community averages.
How do I track Ipamorelin with Alethea Health?
Alethea Health lets you log every Ipamorelin dose, track adherence, sync wearable data (HRV, RHR, sleep), upload lab panels, and correlate changes to your protocol. Free to start — no credit card required.
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Educational reference only — not medical advice. Work with a qualified clinician.