TB-500: Dosage, Protocol, and Research Guide
Synthetic peptide derived from Thymosin Beta-4 that promotes tissue regeneration and repair
Mechanism
Active region of thymosin beta-4 that regulates actin polymerization, essential for cell migration and proliferation. Promotes angiogenesis, reduces inflammation through NF-κB modulation, and enhances stem cell migration to injury sites.
Protocol at a glance
| Starting dose | 300mcg |
|---|---|
| Maintenance dose | 300mcg - 1mg |
| Maximum dose | 1mg |
| Frequency | Daily |
| Typical duration | Up to 90 days, followed by break |
| Route | Subcutaneous |
| Injection site | Any subcutaneous site |
| Timing | Any time of day |
Side effects
- Mild injection site irritation
- Temporary fatigue or dizziness at higher doses
Contraindications
- Cancer or pre-existing tumors
- Pregnancy
Protocol notes
- Regulates actin-binding proteins essential for wound healing
- Stimulates new blood vessel formation (angiogenesis)
- Accelerates recovery in ligaments, tendons, muscle injuries
- Supports connective tissue repair and flexibility
- May enhance nerve regeneration
- Commonly combined with BPC-157 for synergistic healing effects
- Consult provider if cancer history due to angiogenesis promotion
Frequently asked questions
What is TB-500 used for?
TB-500 has been studied for: Synthetic peptide derived from Thymosin Beta-4 that promotes tissue regeneration and repair Mechanism: Active region of thymosin beta-4 that regulates actin polymerization, essential for cell migration and proliferation. For research purposes only — consult a licensed physician before use.
What is the standard TB-500 dose?
Starting dose in published protocols is typically 300mcg, titrating up to a maintenance dose of 300mcg - 1mg (max 1mg). Frequency: Daily. Route: Subcutaneous. Always confirm with a medical professional.
How is TB-500 administered?
TB-500 is typically administered subcutaneous at the any subcutaneous site. Timing: Any time of day. Rotate injection sites to avoid tissue irritation.
What are the side effects of TB-500?
Reported side effects include: Mild injection site irritation, Temporary fatigue or dizziness at higher doses. Individual responses vary. Contact a healthcare provider if you experience unexpected symptoms.
Who should not take TB-500?
Contraindications in published research include: Cancer or pre-existing tumors, Pregnancy. This is not an exhaustive list — consult a physician before starting any peptide protocol.
How long does TB-500 take to work?
Timelines vary by individual and goal. Published protocols run for Up to 90 days, followed by break. Track doses, side effects, and biomarker changes over time to measure your own response rather than relying on community averages.
How do I track TB-500 with Alethea Health?
Alethea Health lets you log every TB-500 dose, track adherence, sync wearable data (HRV, RHR, sleep), upload lab panels, and correlate changes to your protocol. Free to start — no credit card required.
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Educational reference only — not medical advice. Work with a qualified clinician.